On July 16, 2024, the United States Patent and Trademark Office (“USPTO”) issued new guidance on the patentability of AI-related inventions. Although the USPTO emphasized that its guidance does not change the law of 35 U.S.C. § 101, patent applicants and patent litigation defendants are likely to scrutinize the guidance for insights that will help them secure (or as the case may be, to invalidate) new AI-related patents.